Abstract
The methanolic crude extract from the roots of Jacquinia flammea showed moderate antifungal activity against dermatophytes and very strong antifungal activity against Colletotrichum gloeosporioides. The bioassay-guided purification of the extract, using a combination of vacuum-liquid chromatography and high performance liquid chromatography, allowed the identification of sakurasosaponin as the main metabolite responsible for the antifungal activity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antifungal Agents / analysis
-
Antifungal Agents / chemistry
-
Antifungal Agents / pharmacology*
-
Arthrodermataceae / drug effects
-
Chromatography, Liquid
-
Colletotrichum / drug effects
-
Methanol
-
Molecular Structure
-
Plant Extracts / analysis
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology*
-
Plant Roots / chemistry*
-
Primulaceae / chemistry*
-
Saponins / analysis
-
Saponins / chemistry
-
Saponins / pharmacology*
Substances
-
Antifungal Agents
-
Plant Extracts
-
Saponins
-
sakurasosaponin
-
Methanol