Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes

Lene Ringholm; Ulrik Pedersen-Bjergaard; Birger Thorsteinsson; Frans Boomsma; Peter Damm; Elisabeth R Mathiesen

doi:10.1016/j.diabres.2011.06.007

Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes

Diabetes Res Clin Pract. 2011 Sep;93(3):e106-9. doi: 10.1016/j.diabres.2011.06.007. Epub 2011 Jul 7.

Authors

Lene Ringholm¹, Ulrik Pedersen-Bjergaard, Birger Thorsteinsson, Frans Boomsma, Peter Damm, Elisabeth R Mathiesen

Affiliation

¹ Center for Pregnant Women with Diabetes, Rigshospitalet, University of Copenhagen, Denmark. [email protected]

PMID: 21741108
DOI: 10.1016/j.diabres.2011.06.007

Abstract

The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting that preeclampsia is associated with cardiovascular changes in early pregnancy.

MeSH terms

Adult
Atrial Natriuretic Factor / blood*
Diabetes Mellitus, Type 1 / blood*
Diabetes Mellitus, Type 1 / complications
Female
Gestational Age
Humans
Natriuretic Peptide, Brain / blood
Pre-Eclampsia / blood*
Pre-Eclampsia / etiology
Pregnancy
Pregnancy Complications / blood
Young Adult

Substances

Natriuretic Peptide, Brain
Atrial Natriuretic Factor