Abstract
Naturally occurring acetylated pseudoguaianolides and psilostachyin including their analogues were synthesized. The structure of semi-synthetic psilostachyin was also confirmed by X-ray crystallography. The anti-inflammatory potential of all the derivatives has been evaluated through in vitro expression of TNF-α, IL-1β and IL-6 in murine neutrophils.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Crystallography, X-Ray
-
Dose-Response Relationship, Drug
-
Interleukin-1beta / biosynthesis
-
Interleukin-6 / biosynthesis
-
Lactones / chemical synthesis
-
Lactones / chemistry
-
Lactones / pharmacology*
-
Mice
-
Models, Molecular
-
Molecular Conformation
-
Neutrophils / drug effects*
-
Neutrophils / immunology
-
Sesquiterpenes / chemical synthesis
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / pharmacology*
-
Stereoisomerism
-
Structure-Activity Relationship
-
Tumor Necrosis Factor-alpha / biosynthesis
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Interleukin-1beta
-
Interleukin-6
-
Lactones
-
Sesquiterpenes
-
Tumor Necrosis Factor-alpha
-
psilostachyin A