Cytotoxic, antiviral indolocarbazoles from a blue-green alga belonging to the Nostocaceae

J Antibiot (Tokyo). 1990 Oct;43(10):1236-9. doi: 10.7164/antibiotics.43.1236.

Abstract

6-Cyano-5-methoxy-12-methylindolo[2,3-alpha]carbazole and 6-cyano-5-methoxyindolo[2,3-alpha]carbazole are responsible for most of the cytotoxicity and antiviral activity associated with the blue-green alga Nostoc sphaericum EX-5-1. The compounds are active against HSV II and show weak cytotoxicity against KB and LoVo human carcinoma cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology
  • Carbazoles / chemistry*
  • Carbazoles / pharmacology
  • Cell Line
  • Cyanobacteria / metabolism*
  • Cytotoxins / chemistry*
  • Cytotoxins / pharmacology
  • Humans
  • Indoles / chemistry*
  • Indoles / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Simplexvirus / drug effects
  • Spectrophotometry, Ultraviolet
  • Tumor Cells, Cultured

Substances

  • Antiviral Agents
  • Carbazoles
  • Cytotoxins
  • Indoles
  • 6-cyano-5-methoxy-12-methylindolo(2,3-a)carbazole
  • 6-cyano-5-methoxyindolo(2,3-a)carbazole