Pharyngolaryngectomy with free jejunal autograft reconstruction and tracheoesophageal voice restoration: Indications for replacements, microbial colonization, and indwelling times of the Provox 2 voice prostheses

Head Neck. 2011 Aug;33(8):1144-53. doi: 10.1002/hed.21590. Epub 2010 Nov 17.

Abstract

Background: The purpose of this prospective study was to investigate shunt-related and device-related complications and microbial colonization of voice prostheses in patients after pharyngolaryngectomy with jejunal autograft reconstruction in comparison to patients after standard laryngectomy.

Methods: Nine patients after pharyngolaryngectomy with jejunal autograft reconstruction (group 1) and 14 patients after standard laryngectomy (group 2) equipped with the Provox(®) 2 voice prostheses were followed up over 2 years. Anamnestic data, documentation of shunt-related or device-related complications, the Provox(®) 2 indwelling time, and standard microbiological procedures of voice prostheses were used for analyses.

Results: A total of 157 prostheses were replaced. No significant difference in mean prosthesis indwelling time (p = .45) was observed between group 1 (116 ± 114 days) and group 2 (129 ± 99 days). Patients with jejunal autograft reconstruction needed prosthesis replacements more frequently within the first 60 days after prosthesis insertion in comparison to patients after standard laryngectomy (p = .007). The main indication for replacement in both groups was the device leakage (group 1: 93.1%, group 2: 92.1%). Prostheses of group 1 were more often colonized with Staphylococcus aureus (p = .027) and Enterobacteriaceae (p = .015).

Conclusion: This study demonstrated that, in comparison with patients after standard laryngectomy, patients after jejunal autograft reconstruction have similar shunt-related and device-related complications and prosthesis indwelling times. Therefore, tracheoesophageal voice rehabilitation could be strongly recommended in these patients.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Chi-Square Distribution
  • Cohort Studies
  • Colony Count, Microbial
  • Combined Modality Therapy
  • Equipment Contamination
  • Female
  • Follow-Up Studies
  • Humans
  • Jejunum / surgery
  • Kaplan-Meier Estimate
  • Laryngeal Neoplasms / pathology
  • Laryngeal Neoplasms / rehabilitation
  • Laryngeal Neoplasms / surgery
  • Laryngectomy / adverse effects*
  • Laryngectomy / methods
  • Laryngectomy / rehabilitation
  • Larynx, Artificial / adverse effects*
  • Larynx, Artificial / microbiology
  • Male
  • Middle Aged
  • Pharyngeal Neoplasms / pathology
  • Pharyngeal Neoplasms / rehabilitation
  • Pharyngeal Neoplasms / surgery
  • Pharyngectomy / adverse effects*
  • Pharyngectomy / methods
  • Pharyngectomy / rehabilitation
  • Plastic Surgery Procedures / adverse effects
  • Plastic Surgery Procedures / methods*
  • Prospective Studies
  • Prosthesis Failure*
  • Prosthesis-Related Infections / diagnosis
  • Prosthesis-Related Infections / microbiology
  • Prosthesis-Related Infections / surgery
  • Risk Assessment
  • Statistics, Nonparametric
  • Surgical Flaps
  • Transplantation, Autologous
  • Treatment Outcome
  • Voice Quality