Abstract
Labelling antigen-specific T cells with peptide-MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cancer Vaccines / immunology
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Cell Tracking / methods
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Communicable Diseases / immunology
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Epitope Mapping / methods
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Epitope Mapping / trends
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Epitopes, T-Lymphocyte / analysis*
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Epitopes, T-Lymphocyte / immunology
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Flow Cytometry / methods
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Humans
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Immunologic Techniques / trends
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Immunotherapy, Adoptive / methods
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Immunotoxins / immunology
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Immunotoxins / therapeutic use
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Major Histocompatibility Complex / immunology*
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Mass Spectrometry / methods
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Mice
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Peptides / immunology*
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Receptors, Antigen, T-Cell / immunology
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / immunology
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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Vaccines / immunology
Substances
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Cancer Vaccines
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Epitopes, T-Lymphocyte
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Immunotoxins
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Peptides
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Receptors, Antigen, T-Cell
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Vaccines