Cariniferosides A-F and other steroidal biglycosides from the starfish Asteropsis carinifera

Timofey V Malyarenko; Alla A Kicha; Natalia V Ivanchina; Anatoly I Kalinovsky; Pavel S Dmitrenok; Svetlana P Ermakova; Valentin A Stonik

doi:10.1016/j.steroids.2011.06.006

Cariniferosides A-F and other steroidal biglycosides from the starfish Asteropsis carinifera

Steroids. 2011 Nov;76(12):1280-7. doi: 10.1016/j.steroids.2011.06.006. Epub 2011 Jul 7.

Authors

Timofey V Malyarenko¹, Alla A Kicha, Natalia V Ivanchina, Anatoly I Kalinovsky, Pavel S Dmitrenok, Svetlana P Ermakova, Valentin A Stonik

Affiliation

¹ Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.

PMID: 21763335
DOI: 10.1016/j.steroids.2011.06.006

Abstract

Six new steroidal biglycosides, cariniferosides A-F (1-6), were isolated along with six previously known glycosides, 7-12, from the alcoholic extract of the starfish Asteropsis carinifera. The structures of 1-6 were determined by extensive NMR and ESIMS techniques. The isolated compounds did not show any apparent cytotoxicity in cancer cell lines HCT-116, RPMI-7951, and T-47D, but sulfated compounds 6, 11, and 12 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in a soft agar clonogenic assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Glycosides / chemistry*
Glycosides / isolation & purification
Glycosides / pharmacology
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Starfish / chemistry*
Steroids / chemistry*
Steroids / isolation & purification
Steroids / pharmacology
Tumor Stem Cell Assay

Substances

Glycosides
Steroids