Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats

Rocio Bautista-Pérez; Abraham Arellano; Martha Franco; Horacio Osorio; Israel Coronel

doi:10.1016/j.diabres.2011.06.023

Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats

Diabetes Res Clin Pract. 2011 Oct;94(1):e8-11. doi: 10.1016/j.diabres.2011.06.023. Epub 2011 Jul 20.

Authors

Rocio Bautista-Pérez¹, Abraham Arellano, Martha Franco, Horacio Osorio, Israel Coronel

Affiliation

¹ Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, México City, Mexico. [email protected]

PMID: 21775010
DOI: 10.1016/j.diabres.2011.06.023

Abstract

We observed that in isolated perfused rat kidneys, sphingosine-1-phosphate produces S1P(2) receptor-mediated vasoconstriction, and this response increased in kidneys of diabetic rats. These results suggest that the antagonists of S1P(2) receptor may have potential as drugs to control diabetes-induced vascular complications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blotting, Western
Diabetes Mellitus / genetics
Diabetes Mellitus / metabolism*
In Vitro Techniques
Kidney / blood supply*
Kidney / drug effects
Kidney / metabolism*
Lysophospholipids / pharmacology*
Male
Rats
Rats, Wistar
Receptors, Lysosphingolipid / genetics
Receptors, Lysosphingolipid / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Sphingosine / analogs & derivatives*
Sphingosine / pharmacology
Vasoconstriction / drug effects*

Substances

Lysophospholipids
Receptors, Lysosphingolipid
sphingosine 1-phosphate
Sphingosine