In March 2010, the American Cancer Society hosted the National Patient Navigation Leadership Summit. The Summit organizers invited cancer clinicians, researchers, practicing public health and measurement experts, funders, and patient navigators to develop a national consensus on common outcomes to solidify the scientific evidence and efficacy of patient navigation. The goal of the Summit was to develop and propose core metrics to measure outcomes of navigation on individuals as well as populations across the continuum. It is the sincere hope of the editors, funders, authors, and workgroup members that this supplement and the proposed measures provide a roadmap for the development, implementation,and evaluation of patient navigation programs.