Abstract
Hypercalcemia is a rare metabolic disorder in course of B cell lymphoma. The mechanism of hypercalcemia in patients with malignancy may include the increased extrarenal production of vitamin D from tumoral cells or neighboring macrophages, i-PTH or PTHrP from tumoral cells. In this case we reported a 34 years old caucasian woman with acute renal failure and hypercalcemia as onset of splenic lymphoma in absence of abnormal levels of serum vitamin D and PTHrP. Because of dramatic recovery of renal function and hypercalcemia after splenectomy, we can speculate that main mechanism of hypercalcemia is related to vitamin D production from neighboring lymphoma macrophages.
MeSH terms
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Acute Kidney Injury / blood
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Acute Kidney Injury / etiology*
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Adult
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Biomarkers / blood
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Biopsy
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Calcitriol / blood
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Calcium / blood
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Chemotherapy, Adjuvant
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Creatinine / blood
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Female
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Humans
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Hypercalcemia / blood
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Hypercalcemia / etiology*
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Lymphoma, Large B-Cell, Diffuse / blood
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Lymphoma, Large B-Cell, Diffuse / complications*
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Lymphoma, Large B-Cell, Diffuse / diagnosis
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Lymphoma, Large B-Cell, Diffuse / surgery
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Parathyroid Hormone / blood
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Splenectomy
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Splenic Neoplasms / blood
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Splenic Neoplasms / complications*
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Splenic Neoplasms / diagnosis
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Splenic Neoplasms / surgery
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Tomography, X-Ray Computed
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Treatment Outcome
Substances
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Biomarkers
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PTH protein, human
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Parathyroid Hormone
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Creatinine
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Calcitriol
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Calcium