Abstract
We characterized twelve SIV-infected Chinese-origin rhesus macaques for their entire MHC class I allele composition. Several MHC class I alleles were present in animals with varying outcomes of infections, either elite control or normal progression to AIDS disease. These MHC class I alleles may prove interesting targets for additional characterization.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alleles
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Animals
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China
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Disease Progression
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Genes, MHC Class I*
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Histocompatibility Antigens Class I / genetics*
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Macaca mulatta
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Pedigree
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Polymorphism, Genetic
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Sequence Analysis, RNA
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Simian Acquired Immunodeficiency Syndrome / genetics*
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Immunodeficiency Virus / physiology*
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Viremia / genetics
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Viremia / immunology
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Virus Replication
Substances
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Histocompatibility Antigens Class I