Structural and biophysical insight into cholesteryl ester-transfer protein

Biochem Soc Trans. 2011 Aug;39(4):1000-5. doi: 10.1042/BST0391000.

Abstract

CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anticholesteremic Agents / pharmacology
  • Anticholesteremic Agents / therapeutic use
  • Binding Sites
  • Cardiovascular Diseases / drug therapy
  • Cholesterol Ester Transfer Proteins / antagonists & inhibitors
  • Cholesterol Ester Transfer Proteins / chemistry
  • Cholesterol Ester Transfer Proteins / genetics
  • Cholesterol Ester Transfer Proteins / metabolism*
  • Cholesterol Esters / metabolism
  • Conserved Sequence
  • Evolution, Molecular
  • Humans
  • Molecular Sequence Data
  • Phospholipids / metabolism
  • Protein Conformation

Substances

  • Anticholesteremic Agents
  • Cholesterol Ester Transfer Proteins
  • Cholesterol Esters
  • Phospholipids