Association study between sick building syndrome and polymorphisms of seven human detoxification genes in the Japanese

Yasunari Matsuzaka; Yukie Y Kikuti; Akiko Mizutani; Yoshiko Aoyama; Kazuhiko Kakuta; Akira Oka; Hidetoshi Inoko; Kou Sakabe; Satoshi Ishikawa; Jerzy K Kulski; Minoru Kimura

doi:10.1016/j.etap.2009.11.007

Association study between sick building syndrome and polymorphisms of seven human detoxification genes in the Japanese

Environ Toxicol Pharmacol. 2010 Mar;29(2):190-4. doi: 10.1016/j.etap.2009.11.007. Epub 2009 Nov 24.

Authors

Yasunari Matsuzaka¹, Yukie Y Kikuti, Akiko Mizutani, Yoshiko Aoyama, Kazuhiko Kakuta, Akira Oka, Hidetoshi Inoko, Kou Sakabe, Satoshi Ishikawa, Jerzy K Kulski, Minoru Kimura

Affiliation

¹ Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

PMID: 21787601
DOI: 10.1016/j.etap.2009.11.007

Abstract

Sick building syndrome (SBS) is a chronic disorder caused by exposure to diverse indoor environmental or chemical pollutants. This study examined the association between seven detoxification genes (CYP1A1, CYP2E1, EPHX1, GSTM1, GSTT1, GSTP1, and NAT2) and SBS in the Japanese population. One hundred eighty patients with SBS and 401 healthy controls were enrolled in this study. We examined the prevalence for total of eleven genetic polymorphisms of detoxification genes. However, no statistically significant differences in allele and genotype frequency distributions of eleven genetic polymorphisms of these detoxification genes were found between patients and controls. On this basis, we conclude that the polymorphisms that we assessed for the detoxification genes do not contribute to the etiology of SBS.