Abstract
Two patients with systemic capillary leak syndrome (SCLS) were followed up clinically for 5 and 2 years, respectively. Muscle biopsy was performed 1 week after the end of an acute crisis in one patient, and after 3 years in the other. In both cases, muscle capillary basement membranes were extremely thick--more than 15 times thicker than normal. Capillary basement membrane enlargement appears to be a permanent lesion, probably limited to muscle vessels. This finding has not been previously reported in SCLS, and would appear to indicate a relationship with the pathogenesis and severity of the crisis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antigen-Antibody Complex / metabolism
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Basement Membrane / metabolism
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Basement Membrane / ultrastructure
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Biopsy
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Capillaries / metabolism
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Capillaries / pathology*
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Capillaries / ultrastructure
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Capillary Permeability*
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Edema / metabolism
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Edema / pathology
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Edema / physiopathology
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Female
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Fluorescent Antibody Technique
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Humans
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Male
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Microscopy, Electron
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Muscles / blood supply
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Muscles / pathology*
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Muscles / ultrastructure
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Proteins / pharmacokinetics
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Shock / metabolism
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Shock / pathology
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Shock / physiopathology
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Syndrome
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Vascular Diseases / metabolism
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Vascular Diseases / pathology
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Vascular Diseases / physiopathology
Substances
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Antigen-Antibody Complex
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Proteins