Biphenyl and biphenyl ether quinolizidine N-oxide alkaloids from Lagerstroemia indica L

Planta Med. 2011 Dec;77(18):2037-41. doi: 10.1055/s-0031-1280064. Epub 2011 Jul 27.

Abstract

Four new biphenyl and biphenyl ether quinolizidine N-oxide alkaloids, 5- EPI-dihydrolyfoline N-oxide (1), decamine N-oxide (2), lagerstroemine N-oxide (3), and lagerine N-oxide (4), were isolated from the aerial parts of Lagerstroemia indica, and their structures were established by extensive spectroscopic studies. In addition, the inhibitory effects of isolated compounds on rat lens aldose reductase (RLAR) were examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Reductase / drug effects
  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Animals
  • Biphenyl Compounds / chemistry*
  • Biphenyl Compounds / isolation & purification
  • Biphenyl Compounds / pharmacology
  • Chemical Fractionation
  • Cyclic N-Oxides / chemistry*
  • Cyclic N-Oxides / isolation & purification
  • Cyclic N-Oxides / pharmacology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology
  • Ethers / chemistry
  • Lagerstroemia / chemistry*
  • Magnetic Resonance Spectroscopy
  • Plant Components, Aerial / chemistry
  • Quinolizidines / chemistry*
  • Quinolizidines / isolation & purification
  • Quinolizidines / pharmacology
  • Rats
  • Rats, Sprague-Dawley

Substances

  • 5-epi-dihydrolyfoline N-oxide
  • Alkaloids
  • Biphenyl Compounds
  • Cyclic N-Oxides
  • Enzyme Inhibitors
  • Ethers
  • Quinolizidines
  • decamine N-oxide
  • lagerine N-oxide
  • lagerstroemine N-oxide
  • diphenyl
  • Aldehyde Reductase