Fatal post-operative Trichoderma longibrachiatum mediastinitis and peritonitis in a paediatric patient with complex congenital cardiac disease on peritoneal dialysis

Carlos F Santillan Salas; Avni Y Joshi; Neelam Dhiman; Ritu Banerjee; W Charles Huskins; Nancy L Wengenack; Nancy K Henry

doi:10.1099/jmm.0.030718-0

Fatal post-operative Trichoderma longibrachiatum mediastinitis and peritonitis in a paediatric patient with complex congenital cardiac disease on peritoneal dialysis

J Med Microbiol. 2011 Dec;60(Pt 12):1869-1871. doi: 10.1099/jmm.0.030718-0. Epub 2011 Jul 28.

Authors

Carlos F Santillan Salas¹, Avni Y Joshi², Neelam Dhiman³, Ritu Banerjee¹, W Charles Huskins¹, Nancy L Wengenack³, Nancy K Henry¹

Affiliations

¹ Department of Pediatric and Adolescent Medicine, Division of Pediatric Infectious Diseases, Mayo Clinic College of Medicine and Mayo Eugenio Litta Children's Hospital, 200 First Street SW, Rochester, MN 55905, USA.
² Department of Pediatric and Adult Allergy/Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
³ Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

PMID: 21799200
DOI: 10.1099/jmm.0.030718-0

Abstract

Trichoderma longibrachiatum is an emerging pathogen in immunocompromised patients. We report a case of Trichoderma post-operative mediastinitis and peritonitis in a child with complex congenital cardiac disease and functional asplenia. The patient was treated unsuccessfully, initially with caspofungin alone followed by a combination of voriconazole (systemic and topical), caspofungin and intraperitoneal amphotericin B.

Publication types

Case Reports

MeSH terms

Amphotericin B / therapeutic use
Antifungal Agents / therapeutic use
Caspofungin
Child, Preschool
Echinocandins / therapeutic use
Fatal Outcome
Female
Heart Defects, Congenital / complications
Heart Defects, Congenital / surgery*
Humans
Immunocompromised Host
Lipopeptides
Mediastinitis* / complications
Mediastinitis* / drug therapy
Mediastinitis* / microbiology
Mycoses* / drug therapy
Peritoneal Dialysis
Peritonitis* / complications
Peritonitis* / drug therapy
Peritonitis* / microbiology
Postoperative Complications*
Pyrimidines / therapeutic use
Spleen / abnormalities
Triazoles / therapeutic use
Trichoderma*
Voriconazole

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Pyrimidines
Triazoles
Amphotericin B
Caspofungin
Voriconazole