Background: Many primary care physicians begin treatment of asthma patients on the basis of their subjective symptoms. We hypothesized that patients diagnosed as having intermittent asthma on the basis of subjective symptoms by a primary care physician may have their asthma severity underestimated.
Methods: We investigated 293 patients who were in their 20s and diagnosed as having asthma. Two hundred and fifteen patients with intermittent asthma diagnosed on the basis of subjective symptoms were chosen. We evaluated their asthma severity using FEV(1) (% predicted), airway hyperresponsiveness to histamine dihydrochloride, and exhaled nitric oxide level as factors that determine asthma severity.
Results: Among these patients, 27.8% were determined to have moderate or severe asthma by the pulmonary function test. History of childhood asthma was the only significant risk factor for a low pulmonary function. Among the patients, 60.9% showed moderate or severe airway hyperresponsiveness. History of childhood asthma was the only significant risk factor for the increase in airway hyperresponsiveness. Moreover, 53.8% showed a high exhaled nitric oxide level. History of childhood asthma was associated with an increased risk of a high eNO level as determined by univariate analysis, but no significant difference was observed in the comparison by multiple logistic regression analysis. The percentage of subjects classified into the mild group by all of the results of the three tests was only 20.6%.
Conclusion: We showed that asthma severity classified on the basis of only subjective symptoms may be underestimated in young adults. We showed that the diagnosis of mild intermittent asthma needs to be determined carefully.