Enantioselective Diels-Alder reactions of enals and alkylidene diketones catalyzed by N-heterocyclic carbenes

Org Lett. 2011 Sep 2;13(17):4708-11. doi: 10.1021/ol201917u. Epub 2011 Aug 2.

Abstract

An electron-withdrawing group was introduced to the α-position of chalcones, and the resulting alkylidene diketones showed new reactivities with enals under the catalysis of N-heterocyclic carbenes (NHCs). Selective activation of enals affords enolate equivalents that undergo highly enantioselective intermolecular Diels-Alder reactions with the alkylidene diketones. No products that might have resulted from typical homoenolate pathways were observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Catalysis
  • Cyclization
  • Heterocyclic Compounds / chemistry*
  • Ketones / chemistry*
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Aldehydes
  • Heterocyclic Compounds
  • Ketones
  • carbene
  • Methane