Abstract
We evaluated the association between tumor-infiltrating FOXP3+ T cells and clinical outcomes in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue type (OAML). Pretreatment formalin-fixed paraffin-embedded tissues from 42 patients with OAML were stained with 236A/E7 anti-FOXP3 murine monoclonal antibody as well as CD3, CD4 and CD8 antibodies. The amount of FOXP3+ T cells was numerically quantified using an image analysis program. Front-line treatments were as follows: combination chemotherapy (n = 25); radiotherapy (n = 9); doxycycline (n = 6); and wait and see (n = 2). Complete response (CR) was observed in 20 (50%) of 40 evaluable patients. Median progression-free survival (PFS) was 50 months. A high number of FOXP3+ T cells (n = 21, ≥ 180/0.58 mm(2)) showed a higher CR rate (33%vs 71%, P = 0.013) and tendency towards prolonged PFS (48 vs 67 months, P = 0.110). In the combination chemotherapy group, a high number of FOXP3+ T cells was significantly associated with a higher CR rate (29%vs 82%, P = 0.008) and prolonged PFS (17 vs 79 months, P = 0.003). A high number of tumor-infiltrating FOXP3+ T cells correlates with a favorable clinical outcome in OAML patients.
© 2011 Japanese Cancer Association.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antigens, CD / analysis
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Antigens, Differentiation, T-Lymphocyte / analysis
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Caspases / genetics
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Conjunctival Neoplasms / drug therapy
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Conjunctival Neoplasms / immunology
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Conjunctival Neoplasms / pathology
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Conjunctival Neoplasms / radiotherapy
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Disease-Free Survival
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Doxycycline / therapeutic use
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Eye Neoplasms / drug therapy
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Eye Neoplasms / immunology*
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Eye Neoplasms / pathology
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Eye Neoplasms / radiotherapy
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Eyelid Neoplasms / drug therapy
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Eyelid Neoplasms / immunology
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Eyelid Neoplasms / pathology
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Eyelid Neoplasms / radiotherapy
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Female
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Forkhead Transcription Factors / analysis*
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Humans
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Immunophenotyping
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Kaplan-Meier Estimate
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Lacrimal Apparatus Diseases / drug therapy
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Lacrimal Apparatus Diseases / immunology
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Lacrimal Apparatus Diseases / pathology
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Lacrimal Apparatus Diseases / radiotherapy
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Lymphocytes, Tumor-Infiltrating / chemistry
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Lymphocytes, Tumor-Infiltrating / immunology*
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Lymphoma, B-Cell, Marginal Zone / drug therapy
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Lymphoma, B-Cell, Marginal Zone / immunology*
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Lymphoma, B-Cell, Marginal Zone / pathology
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Lymphoma, B-Cell, Marginal Zone / radiotherapy
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Male
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Middle Aged
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Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
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Neoplasm Proteins / genetics
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Orbital Neoplasms / drug therapy
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Orbital Neoplasms / immunology
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Orbital Neoplasms / pathology
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Orbital Neoplasms / radiotherapy
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Prognosis
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Remission Induction
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Republic of Korea / epidemiology
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Treatment Outcome
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Watchful Waiting
Substances
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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FOXP3 protein, human
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Forkhead Transcription Factors
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Neoplasm Proteins
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Caspases
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MALT1 protein, human
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Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
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Doxycycline