Performance of glycogen phosphorylase isoenzyme BB is weak in the detection of patients with non-ST-elevation acute coronary syndrome

Christophe Meune; Karim Wahbi; Simon Weber; Stéphane Zuily; Luc Cynober; Camille Chenevier-Gobeaux

doi:10.1016/j.clinbiochem.2011.07.008

Performance of glycogen phosphorylase isoenzyme BB is weak in the detection of patients with non-ST-elevation acute coronary syndrome

Clin Biochem. 2011 Nov;44(16):1343-5. doi: 10.1016/j.clinbiochem.2011.07.008. Epub 2011 Jul 28.

Authors

Christophe Meune¹, Karim Wahbi, Simon Weber, Stéphane Zuily, Luc Cynober, Camille Chenevier-Gobeaux

Affiliation

¹ Cardiology Department, Université Paris Descartes, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, APHP, Paris, France.

PMID: 21820423
DOI: 10.1016/j.clinbiochem.2011.07.008

Abstract

Objective: To examine the diagnostic performance of glycogen-phosphorylase-isoenzyme-BB (GPBB) combined with cardiac troponin I (cTnI) in acute coronary syndrome (ACS).

Design and methods: Sixty patients with chest pain were investigated; GPBB and cTnI were measured.

Results: ACS was confirmed in 31 patients; cTnI was >0.07 μg/L in 15 patients and GPBB was >10 μg/L in 6 patients. Areas under ROC curves were similar: 0.854 (cTnI+GPBB) vs. 0.843 (cTnI), p=0.728.

Conclusion: Combination of GPBB with cTnI does not improve the detection of ACS.

MeSH terms

Acute Coronary Syndrome / blood*
Acute Coronary Syndrome / diagnosis
Acute Coronary Syndrome / enzymology*
Biomarkers / blood
Chest Pain / blood
Chest Pain / diagnosis
Female
Glycogen Phosphorylase / blood*
Humans
Male
Middle Aged
Troponin I / blood*

Substances

Biomarkers
Troponin I
Glycogen Phosphorylase
glycogen phosphorylase BB, human