The relation between 25-hydroxyvitamin D with peak bone mineral density and body composition in healthy young adults

J Pediatr Endocrinol Metab. 2011;24(5-6):355-60. doi: 10.1515/jpem.2011.052.

Abstract

Objective: The associations between peak bone mineral density (BMD) and body composition with 25 hydroxyvitamin D (25OHD) levels in healthy young adults were evaluated.

Methods: The number of participants was 464; 347 women and 117 men. The mean age was 24.3 years (range 17-31 years). BMD of the lumbar spine, total body and femoral neck (FN) and body composition were measured by dual energy X-ray absorptiometry. Volumetric BMD, bone mineral apparent density (BMAD), of the lumbar spine and FN was calculated.

Results: In females, 25OHD level was positively associated with FN BMD and BMAD (both p<0.01) and negatively with percentage body fat (p<0.001). In males, 25OHD levels had a positive association with total body BMD and lean body mass (p=0.03 and p=0.01).

Conclusions: 25OHD level is a determinant of peak BMD in both sexes. Vitamin D status was associated with body fat in females and with lean body mass in males.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / anatomy & histology
  • Adolescent
  • Adult
  • Body Composition / physiology*
  • Body Weight / physiology
  • Bone Density / physiology*
  • Calcium, Dietary / administration & dosage
  • Female
  • Femur Neck / metabolism
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor Binding Proteins / blood
  • Insulin-Like Growth Factor I / metabolism
  • Lumbar Vertebrae / metabolism
  • Male
  • Reference Values
  • Regression Analysis
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Young Adult

Substances

  • Calcium, Dietary
  • IGFBP3 protein, human
  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor Binding Proteins
  • Vitamin D
  • Insulin-Like Growth Factor I
  • 25-hydroxyvitamin D