Abstract
In this issue of Science Translational Medicine, Gasparian et al. use a clever cell-based screen to identify a family of DNA-binding small molecules-curaxins-that inhibit tumor cell growth and division. The curaxins' mechanism of action pinpoints a new chromatin-remodeling factor as a therapeutic target for cancer.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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DNA-Binding Proteins / metabolism*
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High Mobility Group Proteins / metabolism*
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Humans
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NF-kappa B / antagonists & inhibitors*
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Transcriptional Elongation Factors / metabolism*
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Antineoplastic Agents
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DNA-Binding Proteins
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High Mobility Group Proteins
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NF-kappa B
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SSRP1 protein, human
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Transcriptional Elongation Factors
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Tumor Suppressor Protein p53