Innate immune responses to Pseudomonas aeruginosa infection

Microbes Infect. 2011 Dec;13(14-15):1133-45. doi: 10.1016/j.micinf.2011.07.011. Epub 2011 Aug 2.

Abstract

Innate immune responses play a critical role in controlling acute infections due to Pseudomonas aeruginosa in both mice and in humans. In this review we focus on innate immune recognition and clearance mechanisms that are important for controlling P. aeruginosa in the mammalian lung, with particular attention to those that influence the outcome of in vivo infection in murine models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / immunology*
  • Complement System Proteins / immunology
  • Cytokines / immunology
  • Dendritic Cells / immunology
  • Humans
  • Immunity, Innate*
  • Inflammasomes / immunology
  • Lipopolysaccharides / immunology
  • Lipopolysaccharides / metabolism
  • Lung / immunology*
  • Lung / microbiology
  • Lymphocytes / immunology
  • Macrophages, Alveolar / immunology
  • Mice
  • Mice, Knockout
  • Neutrophils / immunology
  • Pneumonia / immunology*
  • Pneumonia / microbiology
  • Pseudomonas Infections / immunology*
  • Pseudomonas Infections / microbiology
  • Pseudomonas aeruginosa / immunology*
  • Receptors, Pattern Recognition / immunology
  • Signal Transduction / immunology*

Substances

  • Bacterial Proteins
  • Cytokines
  • Inflammasomes
  • Lipopolysaccharides
  • Receptors, Pattern Recognition
  • Complement System Proteins