Methicillin-susceptible Staphylococcus aureus nasal colonization and the risk of subsequent methicillin-resistant Staphylococcus aureus infections among hospitalized patients

Jörg J Ruhe; Leonidez de Guzman; Marie Moss; William Riley; Donna Mildvan; David C Perlman; Brian Koll

doi:10.1016/j.diagmicrobio.2011.05.011

Methicillin-susceptible Staphylococcus aureus nasal colonization and the risk of subsequent methicillin-resistant Staphylococcus aureus infections among hospitalized patients

Diagn Microbiol Infect Dis. 2011 Oct;71(2):163-6. doi: 10.1016/j.diagmicrobio.2011.05.011. Epub 2011 Aug 15.

Authors

Jörg J Ruhe¹, Leonidez de Guzman, Marie Moss, William Riley, Donna Mildvan, David C Perlman, Brian Koll

Affiliation

¹ Department of Medicine, Beth Israel Medical Center, New York, NY 10003, USA. [email protected]

PMID: 21840671
DOI: 10.1016/j.diagmicrobio.2011.05.011

Abstract

Few data exist on the risk of methicillin-resistant Staphylococcus aureus (MRSA) infections among known methicillin-susceptible S. aureus (MSSA) carriers. In a cohort of 2991 hospitalized MSSA carriers, 22 (22%) of 98 S. aureus infections that occurred within a subsequent 6-month period were caused by MRSA. Recent fluoroquinolone use was an independent predictor of MRSA infections (P < .001).

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Carrier State / epidemiology
Carrier State / microbiology
Cross Infection / epidemiology*
Cross Infection / microbiology
Female
Humans
Logistic Models
Male
Methicillin-Resistant Staphylococcus aureus / isolation & purification*
Methicillin-Resistant Staphylococcus aureus / pathogenicity*
Middle Aged
Multivariate Analysis
Nasal Cavity / microbiology
Nasal Cavity / pathology
Odds Ratio
Retrospective Studies
Risk Factors
Staphylococcal Infections / epidemiology*
Staphylococcal Infections / microbiology*
Young Adult