Nonoperative approach to locally advanced rectal cancer after neoadjuvant combined modality therapy: challenges and opportunities from a surgical perspective

Katherine N Fischkoff; Jeannine A Ruby; José G Guillem

doi:10.1016/j.clcc.2011.06.001

Nonoperative approach to locally advanced rectal cancer after neoadjuvant combined modality therapy: challenges and opportunities from a surgical perspective

Clin Colorectal Cancer. 2011 Dec;10(4):291-7. doi: 10.1016/j.clcc.2011.06.001. Epub 2011 Aug 15.

Authors

Katherine N Fischkoff¹, Jeannine A Ruby, José G Guillem

Affiliation

¹ Department of Surgery, Colorectal Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

PMID: 21840772
DOI: 10.1016/j.clcc.2011.06.001

Abstract

This review contains a surgical perspective on the evolution of the nonoperative approach to patients with locally advanced rectal cancer who have a clinical complete response after neoadjuvant combined modality therapy, including accuracy of pathologic complete response identification, the timing between neoadjuvant combined modality therapy and assessment of response, the extent of long-term follow-up, and the likelihood of surgical salvage after an initial nonoperative approach.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Combined Modality Therapy
Humans
Neoadjuvant Therapy*
Rectal Neoplasms / surgery
Rectal Neoplasms / therapy*
Treatment Outcome

Grants and funding

R01 82534/PHS HHS/United States