ChimeraScan: a tool for identifying chimeric transcription in sequencing data

Bioinformatics. 2011 Oct 15;27(20):2903-4. doi: 10.1093/bioinformatics/btr467. Epub 2011 Aug 11.

Abstract

Summary: Next generation sequencing (NGS) technologies have enabled de novo gene fusion discovery that could reveal candidates with therapeutic significance in cancer. Here we present an open-source software package, ChimeraScan, for the discovery of chimeric transcription between two independent transcripts in high-throughput transcriptome sequencing data.

Availability: http://chimerascan.googlecode.com

Contact: [email protected]

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Line, Tumor
  • Gene Expression Profiling
  • Gene Fusion*
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • Neoplasms / genetics*
  • Sequence Analysis, RNA*
  • Software*
  • Transcription, Genetic