Abstract
We report here the identification and characterization of a previously uncharacterized, two-component response regulator gene (orf19.5843) from Candida albicans. Because of its apparent functions in stress adaptation, we have named this gene SRR1 (stress response regulator 1). Disruption of SRR1 causes defects in hyphal development, reduced resistance to stress, and severe virulence attenuation in the mouse model of disseminated candidiasis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Candida albicans / genetics
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Candida albicans / growth & development*
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Candida albicans / pathogenicity*
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Candida albicans / physiology
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Candidiasis / microbiology*
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Fungal Proteins / chemistry
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Gene Expression Regulation, Fungal*
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Genes, Regulator*
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Humans
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Mice
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Mice, Inbred BALB C
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Protein Structure, Tertiary
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Stress, Physiological*
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Virulence