Abstract
Natural killer (NK) activities of fresh and IL-2-precultured peripheral blood mononuclear cells (PBMC) were investigated in 13 elderly subjects before and after thymopentin (TP-5) treatment and in 12 age-matched controls. The NK activity of fresh PBMC was found to be significantly higher in subjects given TP-5 at 50 mg s.c. three times per week for one month. Conversely, this type of treatment with TP-5 did not significantly modify the cytotoxic capacity of IL-2-precultured PBMC.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Aged
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Aged, 80 and over
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Aging / immunology
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Cells, Cultured
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Female
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Humans
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Interleukin-2 / pharmacology
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Killer Cells, Natural / drug effects*
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Killer Cells, Natural / physiology
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / physiology
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Male
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Peptide Fragments / pharmacology*
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Randomized Controlled Trials as Topic
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Thymopentin
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Thymopoietins / pharmacology*
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Thymus Hormones / pharmacology*
Substances
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Interleukin-2
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Peptide Fragments
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Thymopoietins
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Thymus Hormones
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Thymopentin