Assessing atropisomer axial chirality in drug discovery and development

J Med Chem. 2011 Oct 27;54(20):7005-22. doi: 10.1021/jm200584g. Epub 2011 Sep 15.
No abstract available

Publication types

  • Review

MeSH terms

  • Amides / chemistry
  • Drug Discovery*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Legislation, Drug
  • Macrocyclic Compounds / chemistry
  • Models, Molecular
  • Pharmaceutical Preparations / chemistry*
  • Pharmacokinetics
  • Stereoisomerism
  • Structure-Activity Relationship
  • Thermodynamics
  • United States
  • United States Food and Drug Administration

Substances

  • Amides
  • Heterocyclic Compounds, 4 or More Rings
  • Macrocyclic Compounds
  • Pharmaceutical Preparations