Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals

Biochem Soc Trans. 1990 Feb;18(1):56-9. doi: 10.1042/bst0180056.
No abstract available

Publication types

  • Review

MeSH terms

  • Antifungal Agents / metabolism*
  • Azoles / metabolism*
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P-450 Enzyme System / metabolism
  • Fungi / drug effects
  • Fungi / enzymology
  • Fungi / genetics*
  • Mutation
  • Oxidoreductases / genetics*
  • Oxidoreductases / metabolism
  • Sterol 14-Demethylase

Substances

  • Antifungal Agents
  • Azoles
  • Cytochrome P-450 Enzyme System
  • Oxidoreductases
  • Sterol 14-Demethylase