Abstract
Cohesins are evolutionarily conserved essential multi-protein complexes that are important for higher-order chromatin organization. They play pivotal roles in the maintenance of genome integrity through mitotic chromosome regulation, DNA repair and replication, as well as gene regulation critical for proper development and cellular differentiation. In this review, we will discuss the multifaceted functions of mammalian cohesins and their apparent functional hierarchy in the cell, with particular focus on their actions in gene regulation and their relevance to human developmental disorders.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Abnormalities, Multiple / genetics
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Abnormalities, Multiple / metabolism
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Abnormalities, Multiple / pathology*
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Animals
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Cell Cycle Proteins / metabolism*
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Cell Cycle Proteins / pharmacology
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Chromatin / chemistry
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Chromatin / metabolism*
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Chromatin Assembly and Disassembly / drug effects*
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Chromosomal Proteins, Non-Histone / metabolism*
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Chromosomal Proteins, Non-Histone / pharmacology
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Cohesins
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Gene Expression Regulation*
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Humans
Substances
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Cell Cycle Proteins
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Chromatin
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Chromosomal Proteins, Non-Histone