Intergenerational anticipation of disease onset in people with multiple autoimmune syndrome

Giuliana Giardino; Giuseppina Aloj; Emilia Cirillo; Donatella Capalbo; Filomena Maio; Mariacarolina Salerno; Adriana Franzese; Claudio Pignata

doi:10.1016/j.diabres.2011.07.022

Intergenerational anticipation of disease onset in people with multiple autoimmune syndrome

Diabetes Res Clin Pract. 2011 Nov;94(2):e37-9. doi: 10.1016/j.diabres.2011.07.022. Epub 2011 Aug 17.

Authors

Giuliana Giardino¹, Giuseppina Aloj, Emilia Cirillo, Donatella Capalbo, Filomena Maio, Mariacarolina Salerno, Adriana Franzese, Claudio Pignata

Affiliation

¹ Department of Pediatrics, Federico II University, via S Pansini 5-80131, Naples, Italy.

PMID: 21852013
DOI: 10.1016/j.diabres.2011.07.022

Abstract

We compared the intergenerational variations of the clinical phenotype between 30 patients affected with multiple autoimmune syndrome (MAS) and their affected first- and second-degree relatives. Mean age at onset was always significantly higher in the previous generation than in probands for all the considered diseases.

MeSH terms

Adolescent
Adult
Age of Onset
Autoimmune Diseases / diagnosis
Autoimmune Diseases / epidemiology
Autoimmune Diseases / genetics*
Celiac Disease / epidemiology
Celiac Disease / genetics
Child
Child, Preschool
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / genetics
Female
Genetic Predisposition to Disease
Heredity
Humans
Italy / epidemiology
Kaplan-Meier Estimate
Male
Pedigree
Phenotype
Retrospective Studies
Syndrome
Thyroiditis, Autoimmune / epidemiology
Thyroiditis, Autoimmune / genetics
Young Adult