Trisomy 8 in Philadelphia chromosome negative cell preceding the evolution of a Philadelphia chromosome positive clone with the same additional change during imatinib treatment: revisiting the role of genetic instability in chronic myeloid leukemia

MeSH terms

• Antineoplastic Agents / therapeutic use*
• Benzamides
• Chromatography, High Pressure Liquid
• Chromosomes, Human, Pair 8 / genetics*
• Clone Cells / metabolism
• Clone Cells / pathology
• DNA Mutational Analysis
• Dasatinib
• Genomic Instability*
• Humans
• Imatinib Mesylate
• In Situ Hybridization, Fluorescence
• Leukemia, Myeloid, Chronic-Phase / drug therapy
• Leukemia, Myeloid, Chronic-Phase / genetics*
• Leukemia, Myeloid, Chronic-Phase / pathology
• Male
• Middle Aged
• Molecular Targeted Therapy
• Philadelphia Chromosome*
• Piperazines / therapeutic use*
• Preleukemia / genetics
• Preleukemia / pathology
• Protein Kinase Inhibitors / therapeutic use*
• Pyrimidines / therapeutic use*
• Real-Time Polymerase Chain Reaction
• Selection, Genetic
• Thiazoles / therapeutic use
• Trisomy*