Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass

J Cardiothorac Surg. 2011 Aug 19:6:99. doi: 10.1186/1749-8090-6-99.

Abstract

The objective of this study was to investigate the effect of beta blocker on cardiac recovery and rhythm during cardiac surgeries. Sixty surgical rheumatic heart disease patients were received esmolol 1 mg/kg or the same volume of saline prior to removal of the aortic clamp. The incidence of cardiac automatic re-beat, ventricular fibrillation after reperfusion, the heart rate after steady re-beat, vasoactive drug use during weaning from bypass, the posterior parallel time and total bypass time were decreased by esmolol treatment.

In conclusion: Esmolol has a positive effect on the cardiac recovery in cardiopulmonary bypass surgeries.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology*
  • Analysis of Variance
  • Cardiopulmonary Bypass*
  • Chi-Square Distribution
  • Female
  • Heart Valve Prosthesis Implantation / methods*
  • Humans
  • Male
  • Mitral Valve / surgery*
  • Postoperative Complications / prevention & control
  • Propanolamines / pharmacology*
  • Prospective Studies
  • Recovery of Function
  • Rheumatic Heart Disease / surgery*

Substances

  • Adrenergic beta-Antagonists
  • Propanolamines
  • esmolol