Abstract
Breast cancer susceptibility gene 1 (BRCA1) has a central role in chemotherapy-induced DNA damage response. The protein inhibitor of activated STAT (PIAS) family of proteins, PIAS1 and PIAS4, are also necessary for adequate DNA damage repair. To further understand the role of BRCA1 in DNA repair, we examined the mRNA expression of these genes in 133 advanced (stage III-IV) gastric cancer patients using quantitative reverse transcription polymerase chain reaction. All P values were two-sided. The median overall survival was 12.5 months (95% confidence interval [CI] = 9.8 to 13.4 months). Among 59 patients receiving second-line docetaxel, the median overall survival was 25.8 months (95% CI = 9.2 to 42.4 months) for patients with high BRCA1 expression, 19.1 months (95% CI = 3.4 to 34.8 months) for those with intermediate expression, and 9.5 months (95% CI = 8.7 to 10.2 months) for those with low expression (P = .0062). The risk of mortality was higher in patients with low BRCA1 levels compared with high BRCA1 levels (hazard ratio of death = 2.49, 95% CI = 1.03 to 5.97, P = .037). Survival in patients receiving second-line docetaxel-based chemotherapy showed a similar trend with PIAS1 and PIAS4 mRNA expression levels, although the associations for PIAS4 were not statistically significant.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenocarcinoma / metabolism
-
Adenocarcinoma / mortality
-
Adenocarcinoma, Mucinous / metabolism
-
Adenocarcinoma, Mucinous / mortality
-
Adult
-
Aged
-
Aged, 80 and over
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
BRCA1 Protein / genetics
-
BRCA1 Protein / metabolism*
-
Carcinoma / metabolism*
-
Carcinoma / mortality*
-
Carcinoma, Adenosquamous / metabolism
-
Carcinoma, Adenosquamous / mortality
-
Carcinoma, Signet Ring Cell / metabolism
-
Carcinoma, Signet Ring Cell / mortality
-
Carcinoma, Squamous Cell / metabolism
-
Carcinoma, Squamous Cell / mortality
-
Chemotherapy, Adjuvant
-
Docetaxel
-
Female
-
Gene Expression Regulation, Neoplastic
-
Humans
-
Kaplan-Meier Estimate
-
Male
-
Middle Aged
-
Neoplasm Staging
-
Odds Ratio
-
Poly-ADP-Ribose Binding Proteins
-
Protein Inhibitors of Activated STAT / genetics
-
Protein Inhibitors of Activated STAT / metabolism*
-
RNA, Messenger / metabolism
-
Retrospective Studies
-
Small Ubiquitin-Related Modifier Proteins / genetics
-
Small Ubiquitin-Related Modifier Proteins / metabolism*
-
Stomach Neoplasms / drug therapy
-
Stomach Neoplasms / metabolism*
-
Stomach Neoplasms / mortality*
-
Stomach Neoplasms / pathology
-
Taxoids / administration & dosage
Substances
-
BRCA1 Protein
-
PIAS1 protein, human
-
PIAS4 protein, human
-
Poly-ADP-Ribose Binding Proteins
-
Protein Inhibitors of Activated STAT
-
RNA, Messenger
-
Small Ubiquitin-Related Modifier Proteins
-
Taxoids
-
Docetaxel