Enrichment of unstable non-coding RNAs and their genome-wide identification

Methods Mol Biol. 2011:759:87-106. doi: 10.1007/978-1-61779-173-4_6.

Abstract

Cryptic unstable transcripts (CUTs) have been recently described as a major class of non-coding RNAs. These transcripts are, however, extremely unstable in normal cells and their analyzes pose specific technical problems. In this chapter, after a brief introduction discussing general aspects associated with the analysis of non-coding RNAs, we provide details of methods to enrich, map, and quantify this unconventional class of transcripts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cryopreservation
  • Gene Expression Profiling
  • Genome, Fungal / genetics*
  • Genomics / methods*
  • Molecular Sequence Data
  • Polyadenylation
  • RNA Stability*
  • RNA, Fungal / chemistry*
  • RNA, Fungal / genetics*
  • RNA, Fungal / isolation & purification
  • RNA, Fungal / metabolism
  • RNA, Untranslated / chemistry
  • RNA, Untranslated / genetics*
  • RNA, Untranslated / isolation & purification
  • RNA, Untranslated / metabolism*
  • Ribonucleoproteins / isolation & purification
  • Ribonucleoproteins / metabolism
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics

Substances

  • RNA, Fungal
  • RNA, Untranslated
  • Ribonucleoproteins