Abstract
Polyunsaturated fatty acids (PUFAs) have been reported to play a regulatory role in tumour growth progression. In the present study, we have synthesized ester derivatives of two important PUFA viz., linoleic acid (LA) and arachidonic acid (AA) with propofol, a widely used general anaesthetic-sedative agent. The novel propofol ester analogues have been found to inhibit various cancer cell lines in a dose-dependent manner. Moreover, the compounds have been found to induce apoptotic cell death by enhancing the release of cytochrome c and expression of caspase-3. The data of the present study suggest that novel propofol-PUFA esters have strong potential to emerge as effective anticancer agents.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Arachidonic Acid / chemical synthesis
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Arachidonic Acid / chemistry
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Arachidonic Acid / pharmacology
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Caspase 3 / metabolism
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Cell Line, Tumor
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Esters / chemical synthesis
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Esters / chemistry
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Esters / pharmacology
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Fatty Acids, Unsaturated / chemical synthesis
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Fatty Acids, Unsaturated / chemistry*
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Fatty Acids, Unsaturated / pharmacology*
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Humans
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Hypnotics and Sedatives / chemical synthesis
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Hypnotics and Sedatives / chemistry
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Hypnotics and Sedatives / pharmacology
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Linoleic Acid / chemical synthesis
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Linoleic Acid / chemistry
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Linoleic Acid / pharmacology
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Neoplasms / drug therapy
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Propofol / chemical synthesis
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Propofol / chemistry*
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Propofol / pharmacology*
Substances
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Antineoplastic Agents
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Esters
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Fatty Acids, Unsaturated
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Hypnotics and Sedatives
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Arachidonic Acid
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Linoleic Acid
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Caspase 3
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Propofol