The purpose of this study is to describe trends in the annual incidence of cutaneous leishmaniasis in Ouagadougou, Burkina from 1999 to 2005. Data recorded at city health care centers were reviewed. A total of 7,444 cases of cutaneous leishmaniasis were observed, with an annual mean incidence of 1,063.3 +/- 270.8 cases. The M/F sex ratio was 0.9. Mean patient age was 22.8 +/- 13.5 years. Patients older than 15 years accounted for 72.5% of the population. The predominant age bracket was 16-30 years (51.80%).A decrease in incidence was observed from March to June and in December. Peak incidence occurred in September and October. Over the 7-year study period, the average incidence rate was 0.1% +/- 0.04. Since this rate does not reflect the real prevalence of the disease, a prospective study is needed.