Microbial metabolism. Part 13. Metabolites of hesperetin

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5784-6. doi: 10.1016/j.bmcl.2011.08.004. Epub 2011 Aug 9.

Abstract

The fungal culture, Mucor ramannianus (ATCC 2628) transformed hesperitin (1) to four metabolites: 4'-methoxy-5,7,8,3'-tetrahydroxyflavanone (8-hydroxyhesperetin) (2), 5,7,3',4'-tetrahydroxyflavanone (eriodictyol) (3), 4'-methoxy-5,3'-dihydroxyflavanone 7-sulfate (hesperetin 7-sulfate) (4) and 5,7,3'-trihydroxyflavanone 4'-O-α-quinovopyranoside (eriodictyol 4'-O-α-quinovopyranoside) (5). The structures were established by spectroscopic methods.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / metabolism*
  • Antineoplastic Agents / pharmacology
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / metabolism*
  • Antioxidants / pharmacology
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Flavanones / chemistry
  • Flavanones / metabolism
  • Hesperidin / chemistry
  • Hesperidin / isolation & purification
  • Hesperidin / metabolism*
  • Hesperidin / pharmacology
  • Molecular Structure
  • Mucor / chemistry
  • Mucor / metabolism*

Substances

  • Antineoplastic Agents
  • Antioxidants
  • Flavanones
  • Hesperidin
  • eriodictyol
  • hesperetin