Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone

Org Biomol Chem. 2011 Oct 21;9(20):7217-23. doi: 10.1039/c1ob05813d. Epub 2011 Aug 26.

Abstract

An efficient and straightforward approach towards the synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone via imination, α-chlorination, hydride reduction and ring closure was developed. In addition, novel primary β-iodo amines were obtained by regioselective ring opening of these 2-(trifluoromethyl)aziridines using alkyl iodides, and their synthetic potential was demonstrated by converting them into novel α-CF(3)-β-phenylethylamines upon treatment with lithium diphenylcuprate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetone / analogs & derivatives*
  • Acetone / chemistry
  • Alkylation
  • Aziridines / chemical synthesis*
  • Fluorine Compounds / chemical synthesis*
  • Methylation
  • Molecular Structure

Substances

  • Aziridines
  • Fluorine Compounds
  • Acetone