Abstract
Cycloaddition reaction between toluamides and benzonitriles was applied to prepare the 3-arylisoquinolines, and their chemical transformation to the dienes 4 was performed. The ring-closing metathesis (RCM) reaction afforded the desired heterocyclic compounds, benzo[3,4]azepino[1,2-b]isoquinolinones 5 in good yield.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry
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Benzazepines / chemical synthesis*
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Benzazepines / chemistry
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Heterocyclic Compounds / chemical synthesis
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Heterocyclic Compounds / chemistry
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Isoquinolines / chemical synthesis
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Isoquinolines / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Nitriles / chemistry
Substances
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Amides
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Benzazepines
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Heterocyclic Compounds
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Isoquinolines
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Nitriles
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benzo(3,4)azepino(1,2-b)-isoquinolinone
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benzonitrile