Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging

Sara Figueiredo; João Nuno Moreira; Carlos F G C Geraldes; Silvia Rizzitelli; Silvio Aime; Enzo Terreno

doi:10.1039/c1cc14019a

Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging

Chem Commun (Camb). 2011 Oct 14;47(38):10635-7. doi: 10.1039/c1cc14019a. Epub 2011 Sep 1.

Authors

Sara Figueiredo¹, João Nuno Moreira, Carlos F G C Geraldes, Silvia Rizzitelli, Silvio Aime, Enzo Terreno

Affiliation

¹ Department of Life Sciences, Faculty of Sciences and Technology, and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.

PMID: 21881668
DOI: 10.1039/c1cc14019a

Abstract

This communication demonstrates that yeast cell wall particles (YCWPs) are a promising class of nature-inspired biocompatible microcarriers for the delivery of amphipathic/lipophilic imaging reporters. When a paramagnetic MRI agent is loaded, the longitudinal relaxivity per particle at 0.5 T is the highest ever reported for Gd-based systems.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biocompatible Materials / chemistry
Cell Wall / chemistry*
Contrast Media / chemistry*
Drug Carriers / chemistry
Gadolinium / chemistry
Magnetic Resonance Imaging
Magnetics
Melanoma, Experimental / diagnostic imaging
Mice
Radionuclide Imaging
Rhodamines / chemistry
Saccharomyces cerevisiae / chemistry
Saccharomyces cerevisiae / metabolism*

Substances

Biocompatible Materials
Contrast Media
Drug Carriers
Rhodamines
Gadolinium