Abstract
In order to find antiviral compounds with novel structures, geldanamycin and lamivudine with different antiviral mechanisms were conjunctively synthesized to acquire a new compound TC-GM, and the antiviral activity of TC-GM was measured. The antiviral activity against HIV-1 was examined by p24 antigen ELISA kit. The activity against HBV was examined by dotblot. The activity against HSV and CoxB virus was examined by CPE. TC-GM exhibited broad-spectrum antiviral activities similarly like geldanamycin. TC-GM inhibited the replication of different viruses, including HIV-1, HBV, HSV 1 and 2, CoxB6. TC-GM showed more potent inhibitory activity against HIV-1 and HBV than other detected virus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Benzoquinones / chemical synthesis*
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Benzoquinones / chemistry
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Benzoquinones / pharmacology
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Cell Line, Tumor
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Chlorocebus aethiops
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Enterovirus B, Human / drug effects
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Enterovirus B, Human / physiology
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HIV-1 / drug effects
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HIV-1 / physiology
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Hep G2 Cells
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Hepatitis B virus / drug effects
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Hepatitis B virus / physiology
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Herpesvirus 1, Human / drug effects
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Herpesvirus 1, Human / physiology
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Herpesvirus 2, Human / drug effects
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Herpesvirus 2, Human / physiology
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Humans
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Lactams, Macrocyclic / chemical synthesis*
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Lactams, Macrocyclic / chemistry
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Lactams, Macrocyclic / pharmacology
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Lamivudine / chemical synthesis*
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Lamivudine / chemistry
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Lamivudine / pharmacology
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Madin Darby Canine Kidney Cells
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / virology
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Vero Cells
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Virus Replication / drug effects*
Substances
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Anti-HIV Agents
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Antiviral Agents
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Benzoquinones
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Lactams, Macrocyclic
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Lamivudine
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geldanamycin