Synthesis of methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide

Krzysztof Felczak; Krzysztof W Pankiewicz

doi:10.1080/15257770.2011.575909

Synthesis of methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide

Nucleosides Nucleotides Nucleic Acids. 2011 Jul-Aug;30(7-8):512-23. doi: 10.1080/15257770.2011.575909.

Authors

Krzysztof Felczak¹, Krzysztof W Pankiewicz

Affiliation

¹ Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, USA.

PMID: 21888543
DOI: 10.1080/15257770.2011.575909

Abstract

The synthesis of metabolically stable methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide (NAD) is reported. In contrast to natural pyrophosphates, these NAD analogues are able to penetrate the cell membrane and can be used as probes in cellular assays.

MeSH terms

Chemistry Techniques, Synthetic / methods*
Diphosphonates / chemical synthesis*
Diphosphonates / chemistry
NAD / analogs & derivatives*
NAD / chemical synthesis
Pyridones / chemical synthesis
Pyridones / chemistry*

Substances

Diphosphonates
Pyridones
NAD
methylene diphosphonate