No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population

Lifang Wang; Jun Li; Meixiang Jia; Weihua Yue; Yanyan Ruan; Tianlan Lu; Jishui Zhang; Jing Liu; Dai Zhang

doi:10.1016/j.psychres.2011.08.004

No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population

Psychiatry Res. 2011 Dec 30;190(2-3):369-71. doi: 10.1016/j.psychres.2011.08.004. Epub 2011 Sep 3.

Authors

Lifang Wang¹, Jun Li, Meixiang Jia, Weihua Yue, Yanyan Ruan, Tianlan Lu, Jishui Zhang, Jing Liu, Dai Zhang

Affiliation

¹ Key Laboratory for Mental Health, Ministry of Health, Beijing, People's Republic of China.

PMID: 21890215
DOI: 10.1016/j.psychres.2011.08.004

Abstract

Autism is a pervasive neurodevelopmental disorder. CDK5 (cyclin-dependent kinase 5) and its interacting molecules are involved in neurodevelopment. We performed a family-based association analysis between CDK5, NDEL1, and LIS1 polymorphisms and autism in a Chinese Han population. Our study did not detect a significant association. It indicated that common genetic variations in these genes might not play a role in the genetic predisposition to autism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

1-Alkyl-2-acetylglycerophosphocholine Esterase / genetics*
Adolescent
Asian People / ethnology
Asian People / genetics
Autistic Disorder / genetics*
Carrier Proteins / genetics*
Child
Child, Preschool
China / epidemiology
China / ethnology
Cyclin-Dependent Kinase 5 / genetics*
Family Health
Female
Genetic Association Studies
Genotype
Humans
Male
Microtubule-Associated Proteins / genetics*
Polymorphism, Genetic / genetics*

Substances

Carrier Proteins
Microtubule-Associated Proteins
NDEL1 protein, human
Cyclin-Dependent Kinase 5
CDK5 protein, human
1-Alkyl-2-acetylglycerophosphocholine Esterase
PAFAH1B1 protein, human