Abstract
The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Load / methods
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Coinfection / complications
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Coinfection / immunology
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Coinfection / pathology
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Disease Susceptibility
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Interleukin-17 / biosynthesis*
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Intestinal Diseases, Parasitic / complications
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Intestinal Diseases, Parasitic / immunology*
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Intestinal Diseases, Parasitic / pathology
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Lung / microbiology
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Lung / parasitology
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Mice
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Mice, Inbred BALB C
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Mycobacterium Infections / complications
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Mycobacterium Infections / immunology*
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Mycobacterium Infections / pathology
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Mycobacterium bovis / immunology*
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Strongyloides / immunology*
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Strongyloidiasis / complications
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Strongyloidiasis / immunology*
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Strongyloidiasis / pathology