Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea

Takashi Kimitsuki; Mitsuru Ohashi; Yoshihiro Umeno; Takamasa Yoshida; Noritaka Komune; Teppei Noda; Shizuo Komune

doi:10.1016/j.neulet.2011.08.050

Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea

Neurosci Lett. 2011 Oct 17;504(1):28-31. doi: 10.1016/j.neulet.2011.08.050. Epub 2011 Aug 27.

Authors

Takashi Kimitsuki¹, Mitsuru Ohashi, Yoshihiro Umeno, Takamasa Yoshida, Noritaka Komune, Teppei Noda, Shizuo Komune

Affiliation

¹ Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higasi-Ku, Fukuoka 812-8582, Japan. [email protected]

PMID: 21896315
DOI: 10.1016/j.neulet.2011.08.050

Abstract

Although salicylate is one of the most widely used nonsteroidal anti-inflammatory drugs, it causes moderate hearing loss and tinnitus at high-dose levels. In the present study, salicylate effects on the K currents in inner hair cells were examined. Salicylate reversibly reduced the outward K currents (I(K,f)), but did not affect the inward current (I(K,n)). Salicylate blocked the outward K currents in a concentration-dependent manner according to Hill equation with a half-blocking concentration of 1.66mM, and the Hill coefficient of 1.86.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cochlea / drug effects*
Cochlea / physiology
Guinea Pigs
Hair Cells, Auditory, Inner / drug effects*
Hair Cells, Auditory, Inner / physiology*
Membrane Potentials / drug effects
Membrane Potentials / physiology
Patch-Clamp Techniques
Potassium Channels / drug effects*
Potassium Channels / physiology
Sodium Salicylate / pharmacology*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Potassium Channels
Sodium Salicylate