Abstract
A new coumestan (solalyratin A, 1) and a novel cyclic eight-membered α,β-unsaturated ketone (solalyratin B, 3), together with three known compounds, puerariafuran (2), coumestrol (4) and 9-hydroxy-2',2'-dimethylpyrano[5',6':2,3]-coumestan (5), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of spectroscopic analyses. In vitro, compounds 1-5 showed anti-inflammatory activities, with IC(50) values in the range 6.3-9.1 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology*
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Coumarins / chemistry*
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Coumarins / pharmacology*
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Ketones / chemistry*
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Ketones / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neutrophils / drug effects
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Neutrophils / metabolism
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Rats
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Solanum
Substances
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Anti-Inflammatory Agents
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Coumarins
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Ketones
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Plant Extracts
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coumestan