Abstract
A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Cyclams
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DNA / chemistry*
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DNA Cleavage
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Heterocyclic Compounds / chemistry*
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Hydrolysis
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Models, Molecular
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Nucleic Acid Conformation
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Peptide Nucleic Acids / chemistry*
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Substrate Specificity
Substances
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Cyclams
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Heterocyclic Compounds
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Peptide Nucleic Acids
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DNA
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cyclen