Short hairpin RNA screen reveals bromodomain proteins as novel targets in acute myeloid leukemia

Cancer Cell. 2011 Sep 13;20(3):287-8. doi: 10.1016/j.ccr.2011.08.019.

Abstract

Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloid leukemia (AML).